There are two sides to web design: functionality and impact. With functionality, it's key that people know how to use your site. On a desktop site people are used to seeing navigation at the top, or on the left. Putting it somewhere else would be like putting the contents page of the book randomly in the middle. With these sorts of things it's important to adhere to what people are used to seeing. You can certainly add in extras, but the basics should be obvious. With the move into various devices, adaptive or response design is increasingly important.
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